GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9815354 | 1 | rs7646144 | chr3:41853125 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.72 | 4.04E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs76471037 | chr3:41799414 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.52 | 1.95E-19 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs7648357 | chr3:41849670 | ULK4 | chr3:41288091-42003660:- | 0.63 | 9.79 | 2.36E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs7648578 | chr3:41858731 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.72 | 4.27E-20 | Diastolic blood pressure |
| BLCA | cis | rs10935120 | 1 | rs7648990 | chr3:134244390 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.74 | 9.0E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs7648990 | chr3:134244390 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 3.92 | 0.000106 | Height |
| BLCA | cis | rs9815354 | 1 | rs7650227 | chr3:41794937 | ULK4 | chr3:41288091-42003660:- | 0.61 | 9.47 | 2.99E-19 | Diastolic blood pressure |
| BLCA | cis | rs7651039 | 1 | rs7651039 | chr3:15648004 | ANKRD28 | chr3:15708744-15901053:- | -0.24 | -4.48 | 9.65E-6 | Coronary heart disease |
| BLCA | cis | rs9876781 | 1 | rs7651407 | chr3:48443816 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000136 | Longevity |
| BLCA | cis | rs7611238 | 1 | rs7651757 | chr3:195077305 | C3orf21 | chr3:194789015-194991895:- | 0.28 | 5.54 | 5.57E-8 | Body mass index |
| BLCA | cis | rs2251844 | 1 | rs76542740 | chr15:43891512 | ADAL | chr15:43622872-43646094:+ | -0.38 | -4.3 | 2.21E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs76542740 | chr15:43891512 | CATSPER2 | chr15:43922774-43959900:- | -0.33 | -4.77 | 2.65E-6 | Tumor biomarkers |
| BLCA | cis | rs7714584 | 1 | rs76548544 | chr5:150223515 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.14 | 2.09E-9 | Crohn's disease |
| BLCA | cis | rs7655841 | 1 | rs7655841 | chr4:129890790 | C4orf33 | chr4:130014829-130033842:+ | 0.31 | 4.85 | 1.83E-6 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs4263408 | 1 | rs7656037 | chr4:39717965 | RPL9 | chr4:39455747-39460568:- | -0.43 | -7.13 | 5.13E-12 | Plasma amyloid beta peptide concentrations (ABx-40) |